Iodine – Metabolism, and the Immune System

OVERVIEW

Cedar Bear Naturales® Pureodine™ processed XODINE™ iodine, a 'Stabilized' Diiodine-Molecular Iodine (I₂) Glycerite, is not your typical 'nascent' type of iodine that other companies offer. It's different! 

Summarizing its development – the Pureodine™ process (now in its 8th generational iteration) is different and goes beyond the other methods for making this form of iodine. 

One being that Cedar Bear Naturales® was the first in the industry to utilize a totally alcohol-free approach to using glycerin instead of alcohol (or gases) in the making of this diiodide form of iodine for dietary supplement use. The other is that the Pureodine™ process includes specialized equipment (some customized), lab-grade manufacture-standardized methodology and protocols, and an advanced ground-breaking technology exclusive to Cedar Bear®.

That ground-breaking technology is our IHMVAS™ (Integrated Hydro Molecular Vortex Agitation System) accelerator that imparts transformative qualities and enhanced glycero-microencapsulatiing stability, i.e., 'protective caging' of the molecular iodine (I₂), also known as a 'diiodine,' to the finished iodine product. The enhanced microencapsulating property of the Pureodine™ process is similar to the TincTract™ processes' enhancing glycerin's microencapsulating properties in our herbal glycerite concentrates, even though the two unique process technologies, while both utilizing glycerin, utilize different equipment, implements, protocols, and raw component ingredients from each other.   

It's all a patentable development, but we kept it a proprietary trade secret. This all results in an innovative, revolutionary, and unique 'stabilized' molecular iodine glycerite for iodine loading protocols and daily iodine supplementation. And its quality, astounding stability, gentleness, and milder flavor are unmatched by any others for this type of iodine product.

XODINE™ is a 'Standardized' Lab-Grade product produced in a FDA Registered & Inspected facility/operation, that's also NSF GMP Certified, subjected to 3rd Party Lab Analysis & Tests, and is Kosher Certified, Halal Certified, Vegan Certified, and Made in The USA.

A DETAILED REVIEW OF THE SUBJECT

• The Truth About Comparable Iodine Science Studies & Clinical Trials
• 'Nascent' Is An Incorrect Term For Describing This Form of Iodine
• Iodine Deficiencies Are Worldwide & Well Documented
• Iodine's Role In Evolutionary Biology
• Human and Natural Causes Exacerbating Thyroid & Chromosomal Integrity
• All Forms of Iodine Are Not The Same 

We are going to share a rather shocking fact regarding comparable iodine research as relates to nutrition, dietary supplement use, medical posturing, and pevailing government policy. We will also address the incorrect use of the word 'Nascent' for describing this diiodine form of iodine and why it has sabotaged the credibility of singular element based solutions/tinctures of molecular iodine (I₂) in the scientific community for almost a century.

Regarding the two different forms of iodine/iodide product, one – conjoined mineral salt triiodide ( I₃⁻), such as KI and NaI, and the other – single element-based diiodine-molecular iodine (I₂)  .....

There is not a single 'comparative' scientific study or clinical trial regarding the two different forms of iodine/iodides and the differing states of those forms of iodine/iodides resulting from their manufacturing processes and ingredients used in their making. 

That's right! NO head-to-head comparative scientific studies or clinical trials regarding the two forms of iodine/iodides. Yet arbitrary declarations, stances, and posturing are taken by the scientific and medical communities regarding an assumed commonality between the two forms of iodine/iodides based solely of suppositionally-driven logic and a sort of anecdotal thinking that would be considered unacceptable for other subject matters in fact-based science and medicine.

And, regarding the use of the term 'Nascent' for describing a diiodine-molecular iodine (I₂) product .....

It is incorrect and highly unscientific to use of the word 'Nascent' to describe diiodine-molecular iodine (I₂) supplement products, or any other consumable form of iodine products for that matter. The scientific and medical community are not without some grounds for not supporting comparative scientific studies and clincal trials of diiodine-molecular iodine (I₂) preparations to conjoined mineral salt triiodide ( I₃⁻) preparations. But, it's still a weak excuse for not doing comparable scientific studies and clinical trials between the two forms of iodine/iodides regardless.

The term 'nascent,' as popularly and incorrectly used for describing diiodine-molecular iodine (I₂) products, has been used since 1931 and is deeply imbedded in the natural products market psyche as a result. Fact is, describing diiodine-molecular iodine (I₂) products as being 'nascent' is incorrect, unscientific, and has sabotaged the credibility of this dietary supplement form of iodine/iodide in the scientific community. This form of iodine/iodide is not a 'nascent' product in any sense of the meaning or definition. If it were, such iodine products would not be safe, especially for consuming. Correct use of nomenclature, and understanding those terms is everything in the world of science in general, and chemistry specifically.

For instance, "Nascent" is defined as 'forming,' 'coming into being,' 'emerging,' and 'evolving,' which are all, from a chemistry nomenclature perspective, deemed highly unstable and reactionary states. Where diiodine-molecular iodine (I₂) products are concerned, 'nascent' implies that it is the monoatomic (atomic) Iº form of iodine in a free state that is contained in what are actually diiodine-molecular iodine (I₂) products. A monoatomic (atomic) iodine, as a 'free' Iº iodine in fluid systems, by itself (meaning, not organified or bound to), is a highly corrosive and reactive form of iodine, of which diiodine-molecular iodine (I₂) products are not. This is a fundamental fact regarding iodine chemistry.

Companies making and selling differing takes on so-called 'nascent' labeled iodine for supplement use, do not contain Iº in its 'free' state, which would possess 'nascent' kinds of instability and reactivity, but instead such products contain diiodine (I₂) as molecular iodine – that is NOT nascent! 

The science and nomenclature of chemistry clearly designates a diiodine (I₂) form of iodine, the kind used in products that are called 'nascent,' as being radically different from monoatomic (atomic) Iº of iodine, of which Iº, chemically speaking, is closer to the unstable and reactive characteristics of 'nascent.' 

For decades, the makers of other diiodine-molecular iodine products have claimed their product contains monoatomic (i.e., 'atomic') or ionic iodine, one company even referring to its product as 'Atomic' iodine, which, from a chemistry perspective, is absurd and untrue. Such iodine products are not or never were 'nascent' or containing a iodine in the pure free Iº monoatomic state Again, we are referencing fundamental iodine chemistry here.  

With this knowledge and understanding, Cedar Bear® is transitioning to not list 'Nascent' on its product labels and in print and media, which is scheduled to happen by the Fall of 2025. Cedar Bear® will present its Pureodine™ processed diiodine-molecular iodine (I₂) product, XODINE™, as a 'Molecular Iodine.'

Closing on this point, our Pureodine™ processed iodine is NOT a corrosive and reactive 'nascent' monoatomic Iº form of iodine, as the name 'nascent' actually implies, but is more accurately a 'Stabilized' Diiodine-Molecular Iodine (I₂) Glycerite. We call it for what it actually is, and hence, not something it is not. We try our best to adhere to non-contradictory chemistry-accurate nomenclature where our products are concerned.

Iodine is incredibly important for the body. And make no mistake, iodine deficiency, especially sub-clinical Iodine Deficiency Disorders (IDD) of populations worldwide, including North America, are real and not just a 'popular belief' thing, but are verified and recognized by the United States National Institutes of Health (NIH), Center for Disease Control (CDC), American Medical Association (AMA), and the World Health Organization (WHO), regardless of what the government and doctors would have you iodophobically believe.

Iodine is an "essential" mineral for human health and needs, meaning the human body does not make its own iodine but must ingest it, through diet and/or supplementation to get it.

Many evolutionary biologists consider iodine the mineral element that anchors all other minerals in the biological processes of evolution for multi-cellular higher forms of life, hence being called 'The Anchor Mineral.' Iodine possesses the lowest mass to highest weight of the essential mineral elements required by the body, which is one of the reasons it is only needed in trace amounts compared to the other essential minerals. Nevertheless, even in trace amounts, people are still showing iodine-related deficiencies. 

In evolutionary biology, iodine is considered the core antioxidant that enabled the leap to higher forms of life. Antioxidant activity is fundamental to the survival and adaptation of aerobic life and plays a crucial role in the evolution of complex organisms and higher forms of life. For sure, iodine was essential to the evolutionary development of warm-blooded species and their thyroid gland. In fact, some believe that iodine is at the core of mammalian hemispherical brain development and humans' greater degree of functional lateralization and anatomical asymmetry of the brain. This evolutionary development became unique to humans and would not have happened without iodine.   

While other mineral elements are important and essential, Iodine is the most essential mineral element to healthy DNA sequencing and resultant cellular integrity (the epicenter of chromosomal activity – another example of iodine's essential role in evolutionary biology and its role in preventing chromosomal anomalies) from the start of in-utero meiosis through fetal development and childhood on through adulthood. Iodine anchors thyroid activity and, thus, all metabolic activity in the body. Cardiovascular and blood sugar health are just two of the many body systems dependent on a healthy thyroid and adequate iodine intake, uptake, and utilization throughout the body.

The eminent endocrine physician, Broda O. Barnes, MD, specializing in thyroid medicine, proved over a 35 year career that adequate iodine intake was a part of his successful regimes with reversing diabetes and certain heart diseases. Now, add the ubiquitous presence of bromide in foods and beverages, fluoride in municipal water supplies and medicines, and background radiation, that all challenge thyroid and systemic tissue iodine uptake and utilization and the various conditions that result therefrom become even more aparent.

Did you know that bromide is an iodine mimicker and endocrine disrupter and can displace iodine and get trapped in tissue iodine receptors in place of iodine, causing all kinds of undiagnosed and mysterious problems, as well as thyroid hormone imbalances? Many practitioners consider bromide dominance in Americans to be endemic in the population at large, and the cuase of many misdiagnosed and undiagnosed conditions. Only adequate daily iodine intake can reverse bromine loading and re-saturating the thyroid and extrathyroidal tissue iodine receptors with iodine, and keep iodine trapped in the iodine receptors of the thyroid and tissues of the body.  

Since the immune system is embedded into every body system, including the body's metabolic system, the omnipresent immune system relies on the proper functioning of the body's metabolic system to stay strong. Iodine can be incredibly useful in helping to boost the immune system, while also building the immune system at the same time.

There are long-term human and natural caused radioactive events that have caused and continue to exacerbate thyroid function, chromosomal integrity, and immunity, such as human-caused high carbon output industries and natural-caused volcanic activity for instance. But, for North Americans, perhaps the most insidious and ubiquitous presence of active and residual background radiation comes from the human-caused atmospheric, ground-level, and subterranian nuclear bomb testing that took place at the Nevada test site, without compunction, from 1951 to 1992 (41 years). 

Those years of careless unfettered testing resulted in decades of continious barrage after barrage of sand grain sized radioactive particles falling to the ground within a couple hundred miles of the test site, and smaller, but as dangerous and insidious radioactive particles, able to travel the atmospheric jet streams, falling and contaminating the whole of the United States and parts of Canada. Those radioactive particles that fell to the ground, and are everywhere, have a half-life of up to 10,000 years. And no, it's no small amount we're talking of here. The official count of 928 tests over four decades resulted in a massive compounding concentration of radioactive fallout and soil contamination.

Those radioactive fallout particles are in all soils of America, and continue to be taken up and absorbed into fodder crops for livestock, agriculturally grown foods, and ground waters, that all make their way into foods and potable water supplies. The effects are ubiquitous, continuing, and ever present, often of a stochastic nature – not showing up for decades after exposure. Geiger testing of the ground within the couple hundred miles of the testing site still continue to show disturbingly high levels of surface radioactivity, with higher population density or increased recreational use on many of those sites.

More insidious yet, the government keeps upping the threshold safety level for radiation uptake in livestock fodder, foods and water, and exposure and concentrating in livestock and humans, which in every case is much higher now then when safe threshold determinations were first done, intended to give a false impression that somehow there's nothing to worry about regarding radiation incursion upon and into the body, even though there is a steady unticking of cancers, heart diseases, ever increasing autoimmune conditions, lessened immune integrity of populations, etc.  

Now, add Soviet era Chernobyl, Ukraine nuclear disaster, a human-caused event, and Fukushima Daichi nuclear disaster, a natural-caused event, that continues to contaminate the Pacific ocean and surrounding seas at unchecked rates, and the compounding effects of active and background radiation on thyroids, chromosomal integrity and immunity is undeniable. Fact is, Nevada testing after effects, and Chernobyl and Fukushima disasters are ongoing and compounding problems that won't go away for thousands of years.

So, how does one deal with all the active and background radiation humanity is being subjected to at rising, compounding levels? The answer is, that the only effective counter-deterent measure to reducing or preventing the effects of ubiquitous active and background radiation is sustained and adequate intake of non-radiation contaminated iodine-rich foods (which are getting harder to find), or better yet, adequate daily supplemental intake of an appropriate form of iodine, such as XODINE™.  

An important consideration few people, including many health practitioners, are aware of, is that different forms of iodines/iodides are NOT the same and are treated differently in the body relative to their nuanced effect on biological systems. Current science orthodoxy 'assumes,' via suppositional logic, that all forms of iodine act the same on biological systems (specifically the gut enzymes and digestive juices, etc.), even though this aspect has been well studied and scientifically researched, without seriously considering or even studying the differing states they may be in and how biological systems can affect these forms of iodine separately from each other.

Ignoring the distinctive differences between the two forms of consumable iodines/iodides is a prime example of scientific arrogance, and some might say a cognative dissonance-driven sort of arrogance, given that beyond general digestive tract and blood absorption studies and data for iodides, NO actual comparative clinical trials comparing the two different forms of iodines/iodides has, by the scientific community's own admission, been performed. Yet they continue to make and hold to their assumptive suppositional-driven stances, even though no actual comparative clinical trials supports their positions. In other words, convenient suppositions and assumption, though seeming rationally valid at a superficial level, not actual comparative scientific studies or clinical trials, have ruled the iodine narrative, even up to now! 

This was an appalling revelation for L. Carl Robinson, the lead developer of the Pureodine™ diiodine-molecular iodine (I₂) making process, and was the primary reason he set about to do a deeper dive study of what he called 'the Iodine Conundrum,' that led to his conceiving a more rational solution to developing a better 'Fit-For-Use' daily dietary iodine supplement, and provide a more chemically accurate description for this form of iodine/iodide and the differences between the two main forms of consumable iodine/iodides available. 

Cedar Bear® offers its amazing Pureodine™ processed iodine supplement described as a unique 'Stabilized' Diiodine-Molecular Iodine (I₂) Glycerite. This means no other mineral, like is seen with conjoined mineral salt triiodide ( I₃⁻), such as potassium, sodium, etc., is used to make our iodine. Only the mineral element of iodine, as 'molecular' iodine (I₂), also referred to as 'diiodine,' and the solvent glycerin are used in making our unique liquid iodine product utilizing the Pureodine™ process, hence its being classified as a singular element-based mineral compound.

The chemical process of turning the raw molecular iodine (I₂) into our stablized diiodine-molecular iodine glycerite is done through our Pureodine™ process with the IHMVAS accelerator enhancing finished product quality and stability, and done without the addition of other conjoining mineral elements such as potassium, sodium, etc.

Being a Pureodine™ made 'Stabilized' diiodide-based molecular iodine (I₂) means the iodine solution is remarkably stable and with enhanced 'protective caging' of the I₂ molecules. As previously described, we use the term 'stabilized diiodide’ because it more accurately describes the state of our Pureodine™ processed form of iodine than the term ‘nascent’ does.

Cedar Bear® Stabilized Iodine-Molecular Iodine  (I₂), is an alcohol-free iodine supplement, made using our revolutionary proprietary Pureodine™ process, that you can use to help introduce a more gentle and systemically-transitional kind of iodine into your body, where I₂ is of the most acceptable forms of dietary iodine supplement for easy and effective iodization of the bloodstream, provided it is in a safe, and stable state, like Pureodine™ processed XODINE™ Iodine is. It was the first alcohol-free stabilized 'Standardized' diiodone-molecular iodine I₂) of its kind in the industry and to be introduced into the marketplace for iodine loading protocols, and dietary supplement use, and has remained unique and at the forefront ever since.

Cedar Bear® (and its prior iterations) has been involved in providing high-quality natural-based 100% alcohol-free liquid supplement to customers for 40+ years, and they have the knowledge and expertise to help you realize the power that natural herbal and mineral supplements can have for you. 

What follows is how iodine can affect the immune system and how Cedar Bear®'s Pureodine™ made Stabilized diiodine-molecular iodine (I₂) comes into play. It is one of the most chemistry-accurate descriptions and information yet presented for singular element-based diiodine (I₂) of iodine chemistry and its activity in the body. Read on ...

Metabolism and Immune System – Overview of Iodine Chemistry & Biology

The immune system is vital for your body to ward off harmful bacteria, viruses, and harmful incursive pollutints, and to deal with cells that may become destructive to the body. It helps prevent us from getting the flu when others around us are coughing. Your immune system depends on the body's thyroid-driven metabolic systems for the energy and biological factors to fight off illness and dispose of dead cells and neutralized toxins. Without the proper minerals, fuel, and enzymes, along with plenty of water and oxygen intake, the body cannot muster a stable and reliable defense against illness, foreign incursion into the body, or the effects of rapid onset aging.

Metabolism is regulated by hormones produced by the thyroid (called thyronines) and throughout the body. Iodine is the thyroid’s physiological and biochemical 'cornerstone' that is essential to creating these hormones, and without proper amounts of the right form of iodine in the thyroid, specifically as in-vivo biogenic-adapted and stabilized Iº (i.e.,'organified' monoatomic iodide), 'trapped' in the cellular colloid and iodine receptors of the thyroid and cells throughout the body, the entire body is negatively affected. However, this stable 'organified' monoatomic (Iº) form of iodine forms within the thyroid, not outside of it, as this Iº form of iodine, if found in a 'free state' outside the stable and organified environment of the iodine receptors of the thyroid and cells of the body would be toxic and caustic to tissues.

Then there is recent scientific studies that shows that iodine-related activity goes beyond the thyroid gland (though the thyroid represents the lion's share of iodine-related activity in the body), but is also present, to one degree or another, in every cell and system throughout the body. It is here that molecular iodine, as I₂, in a carrier-bound transport form that happens in the digestive tract, is involved in the extrathyroidal sites of the body where it is in turn configured to an appropriate form to be trapped in the iodine receptors of extrathyroidal cells of the body. This direct uptake of carrier-bound  I₂ from the digestive tract into the bloodstream and transport to extrathyroidal sites is described in the following quoted review of a research abstract from the NIH (National Institutes of Health) National Library of Medicine.

Title of Study Review – 'Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator':  "Most investigations of iodine metabolism in humans and animals have focused on its role in thyroid function. However, considerable evidence indicates that iodine could also be implicated in the physiopathology of other organs. We review the literature that shows that molecular iodine (I₂) exerts multiple and complex actions on the organs that capture it, not including its effects as part of thyroid hormones. This chemical form of iodine is internalized by a facilitated diffusion system that is evolutionary conserved, and its effects appear to be mediated by a variety of mechanisms and pathways. As an oxidized component, it directly neutralizes free radicals, induces the expression of type II antioxidant enzymes, or inactivates proinflammatory pathways. In neoplastic cells, I₂ generates iodolipids with nuclear actions that include the activation of apoptotic pathways and the inhibition of markers related to stem cell maintenance, chemoresistance, and survival. Recently, I₂ has been postulated as an immune modulator that depending on the cellular context, can function as an inhibitor or activator of immune responses. We propose that the intake of molecular iodine is increased in adults to at least 1 mg/day in specific pathologies to obtain the potential extrathyroid benefits described in this review." (Ref: Int J Mol Sci. 2021 Jan 27;22(3):1228.)

Of note, Cedar Bear® Pureodine™ processed XODINE™ Iodine, being a stabilized diiodine-molecular iodine (I₂) glycerite, is the exact I₂ form of iodine the above study review abstract recommends for increasing daily molecular iodine (I₂) intake.

It's an oxidative component (i.e., antioxidant) that directly neutralizes free radicals and triggers type II antioxidant enzymes, suppresses inflammatory pathways, enhances healthy stem cell activity and cellular chemoresistance and survival, and an up-or-down regulating immune modulator. And more can be surmised as beneficial ancillary actions from those listed herein, along with yet to be ascertained benefits.

That's evidently what the carrier-bound I₂ form of iodine results in throughout the extrathyroidal tissues of the body, but only when there is an adequate iodine reserve trapped in the thyroid and extrathyroidally throughout the body, which can only happen with adequate daily intake of iodine, which is currently generally not the case, which is why the reviewers proposed increasing the intake of diiodine-molecular iodine (I₂), that can only be done via iodine-rich foods, conjoined mineral salt triiodides, and diiodine-based molecular iodine (such as XODINE™ Iodine), for specific extrathyroidal pathologies to at least 1mg/day, which is many times more than the US governments paltry RDA/DV listing for daily iodine intake. Even so, with rampant and sub-clinical IDDs ubiquitious presence in the population, this also merits consideration for non-pathological tissue iodine loading and daily supplementation to at least the RDA/DV levels recommended in the study review. 

Pureodine™ processed XODINE™ Iodine, being a diiodine-molecular iodine (I₂) configuration is also subjected to digestive juices and enzymatic activity that collapses and dissociates the I₂ into its two constituent I˜ parts, that are also carrier-bound and absorbed from the gut epithelium into the bloodstream, via the sodium–iodide symporter (NIS), and as previously shown, part of the I₂ from the consumed stabilized diiodine-molecular iodine (I₂) remains intact but is also carrier-bound and absorbed into the bloodstream, where both the intact I₂ and dissociated mono iodides (i.e., two I˜) are transported to to appropriate thyroid and/or extrathyroid tissues throughout the body.

All consumed iodine/iodides, regardless of source or form, whether from foods, conjoined mineral salt triiodides, or diiodine-molecular iodines, once consumed and in the digestive tract, go through a highly sequentiated series of digestive juice and enzymatically-driven states, that concludes with absorption into the bloodstream and transport to the thyroid (I˜) or extrathyroid sites (I₂), where in the thyroid I˜ is turned into the biogenic-adapted monoatomic form of organified Iº that the thyroid sequesters and utilizes, and the molecular iodine (I₂) is extrathyroudally converted and utilized by the other cells and tissues of the body.,  

In the instance of I˜, if the thyroid doesn’t absorb, convert to Iº, and biogenically organify the Iº, and trap it in the thyroid's iodine receptors, it has to work harder to produce even less than needed thyroid hormones, and it can cause swelling and inflammation that leads to a goiter and stoppage of thyroid hormone production altogether.

The science clearly shows that a gross deficiency of iodine at the thyroid's iodine receptors is a major cause of goiters. Goiters are a swollen thyroid gland condition and represent a full-on clinical Iodine Deficiency Disorder (IDD). Goiters can manifest in either a hypothyroid or hyperthyroid condition. Goiters (along with bulging eyeballs) represent the most serious outward manifestations of a full-on clinically-based hypothyroid or hyperthyroid condition and require medical interventions. 

It is often believed that vitamin C and vitamin D are the 'go-to' for what you need for a healthy and strong immune system. While these and balanced levels of other vitamins and minerals are important and should not be ignored, iodine is seen by many as being the anchoring and most foundational to a strong, healthy immune system. Many problems that appear to be vitamin C deficiency related, for example, may be more indicative of an iodine deficiency, especially if a vitamin C regime is minimal or doesn't resolve a condition it is recommended for. Many unresolved conditions utilizing other nutritional supplements are often resolved when a Pureodine™ made stabilized diiodine-molecular iodine (I₂) glycerite is used, either by itself or in combination with those other nutritional supplements, especially selenium, which is essential to iodine utilization in the body.

As earlier described, iodine is great for providing direct immune system support and maintaining DNA sequencing integrity. Iodine helps keep cells healthy and normal, and when at adequate tissue iodine saturation levels, helps keep the body free of toxins. An internal environment rich in iodine is unable to host harmful bacteria, viruses, and fungi that make us sick, and it has been found that these microorganisms cannot adapt to an iodine-enriched tissual environment.

The amazing part of this is that compared to other minerals and vitamins intake, the amount of our Pureodine™ processed XODINE™ Iodine of diiodine-molecular iodine (I₂) intake is extremely small. Only 6 drops a day! (3 to 4 drops for children.) Yet it provides more than the absurdly low government's Recommended Daily Allowance (RDA)/Daily Value (DV) listing, while appearing still low enough to not trigger a W-C Effect (addressed later) in the body, that when compared to the huge benefits resulting therefrom, makes our XODINE™ iodine one of the most astounding value propositions of all essential nutrient supplements there is.

Where Iodine is Found

Iodine is found naturally all over the world, in some soils, in the oceans, the atmosphere (especially over the oceans), and in deep earth venues. Cedar Bear®’s raw iodine used in the making of its Pureodine™ made stabilized diiodine-molecular iodine (I₂) glycerite is from deep earth sources that, unlike ocean-sourced iodine, have been protected for eons against atmospheric and surface contamination, radiation (background and incursive), and modern pollutants.

While it may be remotely possible to get enough unimpeded iodine intake from diet alone, which is extremely rare, most people worldwide are susceptible, to one degree or another, to iodine deficiency due to a number of reasons. Recently, iodine deficiency has gained awareness, and so it is becoming more widely available. Historically, iodine, as potassium iodide, has commonly been added to table salt to provide an easy method of iodine access. It is estimated that around 70 percent of people around the world have access to iodized table salt, though it may be their only source of iodine supplementation available. however, the iodine in iodized salt liberates and dissipates due to its generally being in paperboard-based containers that expose the salt and potassium iodide to ambient air, and if left on shelves too long without using, which warehoused iodized table salt is often subjected to, iodized salt looses most of its iodine to sublimation (i.e., liberating as a vapor due to ambient air exposure).

Up until the early 1980s, America mandated that iodine not only be added to table salt, but also be added to all commercial grain-based bakery goods, with no bromides allowed. After the mandate was lifted and iodine was no longer required in baked goods, bromides were almost immediately added to commercial flours and baked goods as 'bleaching aids,' and 'dough conditioners,' to the point that bromides, and their iodine displacing and endocrine disruptor effects, are ubiquitous in baking flours and commercial baked goods. Bromides are 'iodine mimickers,' meaning they can displace iodine from the body's tissue iodine receptors and attach to those iodine receptors in the event the body is confronted with bromide-loading that overcomes tissue iodine levels in the body. That point alone is reason enough to substantially increase daily iodine intake with XODINE™ Iodine.

Some claim to be 'allergic' to iodine because they cannot eat shellfish, which causes reactions. Well... an allergy is caused by a 'protein,' not a mineral. This is an indisputable fact! One cannot be allergic to a mineral because a mineral is not a protein, this includes iodine. The shellfish contains a protein causing an allergy, not the iodine.  

Aside from the limited availability in foods, Iodine is also consumed as a dietary supplement. Many live in places where the soil does not have enough available iodine traces to make its way into the food chain, especially where bromine/bromide-containing chemicals are widely used on soils and growing foods, which is now found across most of the planet's landmass, which makes iodine supplementation necessary, especially if the government's absurdly low RDA/DV for iodine is held to and not raised, which will guarantee population-wide deficient iodine intake that may cause sub-clinical IDD for many and full-on clinical IDD for some. Iodine supplements can be found in liquids, tablets, capsules, and, as mentioned before, iodized table salt (if it hasn't been warehoused for too long before getting on to store shelves). In typical settings, the iodine is in the form of a conjoined mineral salt triiodide (I₃⁻), the most common being potassium iodide or variants thereof, and that kind of iodine may not be the best 'Fit-For-Use' iodine for daily dietary supplementation, as you will see in the next section.

The Pureodine™ Process – An Industry and Marketplace First!

Cedar Bear® Glycerite of 'Stabilized' Molecular Iodine – A Diiodide (I₂)

First developed in 2007, the proprietary Cedar Bear® Pureodine™ process results in a  singular element-based diiodine of stabilized molecular iodine (I₂) (that contains no other conjoined mineral salts), combined with glycerol molecules in a transformed, stability enhanced, 'protective cageed' matrix state. It's unique to Cedar Bear®'s Pureodine™ process and a first in the iodine tissue loading and dietary supplements industry.

After Cedar Bear® introduced a glycerite of stabilized diiodine-molecular iodine (I₂) into the market, others attempted to duplicate our glycerite-based iodine approach, both as conjoined mineral salt triiodides (I₃⁻),  and other molecular iodine (I₂) products that were/are alcohol-based. However, they are not made the same way nor possess the unique qualities that a Pureodine™ process, with its IHMVAS accelerator, imparts to its stabilized diiodine-molecular iodine (I₂), such as being milder tasting, gentle on oral and gut tissues, more transitional breakdown and carrier-binding processes in the gut, and sustained uptake into the bloodstream of both the I˜ constituent parts of the I₂ molecule and intact I₂ molecule itself, requiring less per daily dose for anticipated benefits than other diiodine-molecular iodine products. 

A Pureodine™ made XODINE™ Iodine is made using deep-earth-sourced pure USP-Grade iodine in its crystaline molecular (I₂) state, along with USP-Grade Kosher and Halal Certified GMO-Free vegetable glycerol (glycerin), and is never conjoined, bound to, or in combination with any other mineral element like other conjoined mineral salt triiodides (I₃⁻), such as potassium, sodium, etc. 

For instance, Lugol’s solution of iodine, derived from raw iodine crystals, as molecular iodine I(I₂), is conjoined with potassium, and Iosol™ iodine is conjoined with sodium, resulting in a triiodide (I₃⁻) of iodine. These manufactured chemically reduced conjoined mineral salt triiodides, and others like them, when entering the stomach, readily give up iodide, as I˜, to the blood stream very quickly with little or no digestive juice or  enzymatic activity, which may account for why conjoined mineral salt triiodides, such as KI (Potassium Iodide), is the preferred prophylactic, in sudden high 'shocking' doses,, that in turn causes the Wolf-Chaikoff Effect (W-C Effect) of quickly suppressing thyroid iodine uptake of radio isotope iodine (and all other forms of iodine) in the event of a nuclear or radiation fallout crisis. Here is where conjoined mineral salt triiodide is a definite 'Fit-for Use' emergency protocol.

On the other hand, a stabilized diiodine-molecular iodine (I₂) does not collapse and dissociate into its constituent I˜ parts as readily and release the mono iodide of I˜ into the bloodstream as quickly as conjoined mineral salt triiodides do to trigger a W-C Effect. This is because a diiodine-molecular iodine, as I₂, is more stable in solution, including the gut, and especially in a glycerite-based solution, and thus in the gut requires a more complex digestive juice and enzymatic process to collapse and dissociate the I₂ into its two constituent I˜ parts, with the I˜ becoming carrier-bound and then absorbing into the bloodstream, and, a portion of the consumed I₂ remains intact, and is then carrier-bound and absorbed into the bloodstream to be transported to extrathyroidal cellular sites.  The guts handling of diiodine-molecular iodine (I₂) accounts for why this form of iodine is more gentle on the digestive system and the body, more transitional preparation, and its slower uptake of the mono iodide (I˜) and molecular iodine (I₂) into the bloodstream, thus being more gentle on thyroid and systemic extrathyroidal tissue uptake of iodine and not as readily triggering a Wolff-Chaikoff Effect that in turn paradoxically supresses thyroid and systemic extrathyroidal  tissue iodine uptake.

The aforementioned phenomenon of the Wolff-Chiakoff (W-C) Effect, causes the thyroid and extrathyroidal tissues throughout the body to suppress the uptake of all iodine/iodides for a time if too much iodine, as mono iodide (I˜), concentrates to high of spiking level in the blood at any one time or compounds to a high concentration over a sustained period of time without backing off.

The primary purpose the body enters into the W-C Effect is to prevent runaway thyroid hormone synthesis in the face of mono iodide (I˜) overload. This knowledge explains why utilizing conjoined mineral salt triiodide (I₃⁻) as an emergency prophylactic, in sudden high milligram amounts per dose (called 'shocking'), with its sudden flushing of mono iodide (I˜), suppresses the uptake of all iodine/iodides, especially radio-isotope-bound iodine in the event of radiation fallout from a nuclear event.

While the W-C Effect causes thyroid and extrathyroidal tissue suppression of iodine uptake by shutting down 'organification' of iodide, once the sudden high flushing of mono iodide of I˜ abates or intake stabilizes, the 'Escape Phenomenon' follows, that allows the thyroid to 'escape' from the W-C Effect and resume normal iodine uptake and hormone synthesis via down-regulation of the sodium–iodide symporter (NIS) lowering intracellular iodide concentration, bringing it back below the inhibitory threshold.

The W-C Effect can happen with any form of iodine/iodide, because all forms provide mono iodide (I˜) to the bloodstream, though a conjoined mineral salt triiodide (I₃⁻), due to its faster collapsing, dissociating, and releasing of mono iodide (I˜) into the bloodstream, would be deemed more susceptible to triggering a W-C Effect than diiodine-molecular iodines (I₂) are. This is due to the different state of the two different forms of iodine and how they interact with the digestive system. Even so, both forms of iodine/iodides can result in a W-C Effect if too much mono iodide (I˜) from either form of iodine/iodides flushingly absorbs from the digestive system into the blood stream, spiking too quickly at any one time, or potentially from over-concentrating from over-consuming due to the resultant mono iodide (I˜) compounding to too high levels in the blood stream over a short period of time. 

Given this information, it appears that one of the major differences between a conjoined mineral salt triiodide, such as KI or NaI, versus a diiodine-molecular iodine, such as XODINE™ Iodine, is there iappears to be a more biologically-friendly drawn-out moderating of mono iodide of I˜ dissociating from the diiodine-molecular iodine (I₂) molecule, and being carrier-bound and more measuredly absorbed into the bloodstream, thus substantially reducing triggering of the W-C Effect. This premise is based on what we know regarding digestive process effects on the different forms of ingested iodines as triiodides (I₃⁻) versus diiodines (I₂), given the studied and known gut biochemistry of collapsing and dissociating mono iodide (I˜) from both forms of consumable iodides for carrier-binding and absorption into the bloodstream. The upshot being that a diiodine-molecular iodine (I₃⁻) may possess a sort of better in-vivo biological compatability, stability, and more gentle transitional presentation of I˜ (and delayed secondary absorption and transport of I₂) to the bloodstream that works more in harmony with the biochemical and physiological  iodine needs of the thyroid and extrathyroidal tissues throughout the body.

It is further observed in actual use of the two different forms of iodine/iodides that whereas the conjoined mineral salt triiodide (i.e., KI and NaI) can have harsh and unsettling effects on the digestive system due to the rapid collapsing and dissociating of the conjoined mineral salt of iodides, the diiodine-molecular iodine (I₂), especially the alcohol-free Pureodine™ made XODINE™ Iodine, due to its slower and transitory collapse and dissociation into its constituent parts, is deemed more gentle and digestive-friendly on the gut, thus indicating another noted and observed difference between the two different forms of iodine/iodide.

This latter point clearly indicates that conjoined mineral salt triiodides (Ki, NaI, etc.) may NOT be the best source of daily dietary iodine supplementation, considering there is a better option available. When compared to diiodie-molecular iodine (I₂), a conjoined mineral salt triiodide might even be considered 'Not-As-Fit-for-Use' for iodine tissue loading or effective daily dietary supplemental purposes, meaning, if both forms of iodine are available, the diiodine-molecular iodine (I₂), such as XODINE™ Iodine, is the better choice.

The aforementioned easier triggering of the W-C Effect with conjoined mineral salt triiodides, such as KI and NaI, is why this form of iodine is such a good go-to prophylactic for staunching the uptake and effects of radio-isotope bound iodine and affected heavy metal incursions from a nuclear event and its radiation fallout, because conjoined mineral salt triiodides, especially when given in high 'shocking' doses, more radically, through its rapid flushing of mono element iodide (I˜), suppresses and stops the thyroid and extrathyroidal tissues of the body from receiving and up-taking radiation laden iodine, and all other kinds of iodine as well, than a diiodine-molecular iodine (I₂) might or appears to be capable of doing to the same degree. Again, indicating another noted and observed difference between the two different forms of iodine/iodides, clearly showing that each appears to be suited to a 'Fit-for-Use' aspect different from each other. Nevertheless, given that no comparative studies have been performed regarding this premise, it is still a subjective perspective, though given what we know of the digestive dynamics and biochemical aspects of the two different forms of iodine products from iodine gut studies, the stated premise appears more likely than not.  

It's surprising that the proven and well elucidated W-C Effect of iodine, especially regarding mono iodide of 1˜ acute blood iodine loading effects, is missed, passed over, or ignored by most doctors, practitioners, dietitians/nutritionists and even many holistic oriented practitioners. Some have even maligned or denied the results of the multiple studies the W-C Effect has been subjected to, right down to ignoring follow-up scientific studies to the original 1948 Wolff-Chaikoff study and Wolff's re-review of the study in 1969. Those follow up studies include the 1988, 2001, and 2014 landmark studies that dived deeper into a highly detailed biochemistry of the subject matter, and clearly verified and detailingly further elucidated the W-C-Effect. Make no mistake, the W-C Effect is real, and is as it has been studied and elucidated for almost 80 years now. Those who say otherwise have typically only made a shallow or cursory study of the subject and base their views and opinions on an incomplete understanding of the facts, or blindly side with speculative assumptions of others, based on a cafeteria pick-n-choose approach of the available information.

Cedar Bear® founder, L. Carl Robinson, TT, CCHt, RH(AHG), became aware of the W-C Effect and its ramifications to human biology through his studies of IDD (Iodine Deficiency Disorders) that led to a deep dive search into what he called the 'Iodine Conundrum.' As a result, he resolved to figure out the facts regarding the different forms of iodine, how they are dealt with in the body, and their effects in the body, and as a result of his findings, develop an alcohol-free solution to the problem by pursuing the development of a glycerite of diiodine-molecular iodine (I₂) supplement with transformative and enhanced microencapsulating (i.e., protective caging) properties, and enhanced stability, primarily for safe daily dietary supplement use. What Carl developed is quite revolutionary for this form of iodine supplement, and is different, on many levels, from other similar types of diiodine-molecular iodine products.

Cedar Bear® Pureodine™ processed iodine, sold under the Cedar Bear® brand XODINE™, and made available to private label endeavors as well , is NOT a conjoined mineral salt triiodide (I₃⁻), but is a glycerite of stabilized diiodine-molecular iodine (I₂), meaning the only mineral element present in our product is iodine (no other mineral element present), in a transformed, highly stable state. It's a form of iodine that appears to work more hand-in-hand with the body's digestive, metabolic, thyroid, and extrathyroidal needs, since, on a microgram-for-microgram basis, it would possess less of a potential for a W-C Effect than conjoined mineral salt triiodides do, due to its slower, sustained, and transitional release of mono iodide (I₂) into the bloodstream, which is a scientifically established fact regarding how the digestive tract deals with both forms of iodine/iodides.

One point that needs to be noted is that some other makers of iodine supplements mix a finished diiodine-molecular iodine (I₂) with a conjoined mineral salt triiodide (I₃⁻), such as potassium iodide or sodium iodide, and claim the end product is still a diiodide-based molecular (i.e., nascent) iodine, which it is not.

Chemically speaking this is not possible since when molecular iodine, either as a stabilized diiodide-molecular iodine or pure raw iodine crystals or pure mono iodide of I˜, of any form, is mixed with conjoined mineral salt triiodide, such as is done in strengthening the iodine percentage of Lugol's potassium iodide solution during its making, the added iodine (as molecular iodine, or mono eiodide I˜), converts and combines with the conjoined minerals salt triiodide, thus fully becoming a conjoined mineral salt triiodide, possessing more W-C Effect potential than a straight diiodine-molecular iodine (I₂) solution appears to possess.

The Microencapsulating Effect of Glycerin & the Pureodine™ Process

L. Carl Robinson, as lead developer, with a small team of co-developer specialists with backgrounds in nuclear science & electrics, and systems engineering theory, created the Pureodine™ technology. It's a proprietary 'transformative' stabilizing liquid iodine making process, that includes our proprietary IMVHAS (Integrated Hydro Molecular Vortex Agitation System) accelerator technology to create our innovative and revolutionary high-quality stable glycerite of diiodine-molecular iodine (I₂) supplements without alcohol or other conjoined minerals in a way never before done. This was an industry first for dietary supplement-based iodine products and the first of its kind introduced into the marketplace. The Pureodine™ process is a patentable development but we decided to keep it a proprietary trade secret.

As mentioned, the IMVHAS accelerator technology imparts a theoretical  'transformative' weak energy field to the I₂ aenriched glycerite solution, and a stability-enhancing property to this form of iodine/iodide. Now, orthodox science continues to dismiss, and even malign this premise even though chemistry fundamentals teach that when a solution of polarized (ionic) elements or a polarized solute compound, such as our glycerite of molecular iodine (I₂) solution is, when subjected to an energy field, that energy field has, to one degree or another, an energy capturing or 'transforming' effect on the subject being subjected to an energetic field. So from a purely chemical perspective, yes! A Pureodine™ processed diiodine-molecular iodine (I₂) solution IS also an energetically affected (i.e., transformed) product, that would possess unique qualities apart from that of other iodine/iodide products. Hey! We're talking fundamental chemistry and basic molecular physics here!  

Further, unlike other diiodine-molecular iodine products, Cedar Bear®'s glycerite of diiodine-molecular iodine (I₂) solution also possesses a unique stability, imparted by the Pureodine™ process, enhancing the microencapsulating property (i.e., 'protective caging') of glycerin around the iodine molecules (see the above illustration). It's also believed to be why a Pureodine™ processed iodine is so stable, gentle on tissues, and possesses a milder taste for this type of iodine product. This enhanced microencapsulating property, and its effect on enhanced stability, is absent in other diiodine-molecular iodines (whether alcohol, gas, or glycerin based), or conjoined mineral salt triiodide products. This Pureodine™ microencapsulating enhanced property of glycerin is also present in our proprietary TincTract® processed liquid herbal glycerite concentrates, even though different equipment, implements, and manufacturing protocols are used for each.

Over the years since Cedar Bear® first developed the Pureodine™ process for making XODINE™ Iodine, others have tried to do their own glycerite versions of a diiodine-molecular iodine, but haven't matched the Pureodine™ IMVHAS accelerator technology, or enhanced microencapsulating stability, more pleasant taste, and gentler per-dose effectiveness and value of Cedar Bear®'s Pureodine™ processed glycerite of diiodine-molecular iodine (I₂). This is because our Pureodine™ processed diiodine-molecular iodine really is different from all others.

On a final note, an essential benefit of glycerin being used in the making of Pureodine™ processed iodine is that glycerin is much easier on the body than alcohol, residual gases or toxic chemical residues, even possessing nutritive qualities, and assists the body to easily assist gut conversion into an absorbable iodide state (I˜) that is the only form of iodines that can be converted inside the thyroid into monoatomic iodine (Iº), then instantly organified and trapped in the iodine receptors of the thyroid and cells of the body and utilized at the cell level and for all of the body's iodine-based biological needs. Cedar Bear® Pureodine™ made diiodine-molecular iodine (I₂) glycerite begins to be digested (i.e., collapses), dissociated into its constituent parts, and absorbed into the bloodstream at a more biologically-friendly level, and from there utilized by the thyroid and extrathyroidal tissues of the body in a transitionally sustained fashion.

To use Cedar Bear® Pureodine™ made diiodide-based (I₂) molecular iodine glycerite, all it takes is a daily dose of six drops (3 to 4 drops for children) in a glass of purified or distilled water. Drink the water for a light tasting, alcohol-free 'Fit-for-Use' daily iodine supplement that can help provide the iodine your body and immune system need.

So, there you have it! A detailed introduction to Cedar Bear Naturales® Pureodine™ made diiodine-molecular iodine (I₂) glycerite, and one of the most chemistry-accurate presentations regarding diiodine-molecular iodine, as a dietary supplement, in general, and Pureodine™ processed stabilized and microencapsulate-enhanced glycerite of diiodine- molecular iodine (I₂) specifically. Cedar Bear® XODINE™ Iodine is clearly thought out, a carefully executed technology, and the most chemical-accurate understood and elucidated of this form of iodine supplement there is. The choice is clear – XODINE™ Iodine!  

Get Your Cedar Bear® Glycerite of Diiodine-Molecular Iodine – XODINE™