XODINE® Iodine – The Original – Metabolism, and the Immune System

By L. Carl Robinson, MH, FH, TT, CCHt, RH(AHG) – a member of the American Chemical Society (ACS) – Lead developer of the Pureodine™ process, and dietary supplements industry SME on molecular iodine (I₂) chemistry and its biology.

OVERVIEW

Cedar Bear Naturales® Pureodine™ processed XODINE™ Molecular iodine, a 'Stabilized' Diiodine-Molecular Iodine (I₂) Glycerite, is not your typical 'nascent' type of iodine that other companies offer. It's different! For one, coming on to 20 years, it's the first and original alcohol-free 'glycerite' of molecular iodine developed for supplemental use. Yes! The FIRST and ORIGINAL!  

Summarizing its development – the Pureodine™ process (now in its 8th generation iteration) is different and goes beyond the other methods for making this form of iodine. XODINE™ Molecular Iodine is an alcohol-free glycerite of diiodine-molecular (I₂) iodine. It's the original and the first of its kind in the dietary supplements industry. That means we have been doing alcohol-free glycerin-based molecular (I₂) iodine longer than anyone else, and are more experienced in this kind of iodine chemistry, evidenced by:  

• Cedar Bear Naturales® being the first in the industry to utilize a totally alcohol-free approach to using glycerin instead of alcohol (or gases) in the making of this diiodine form of iodine for dietary supplement use.
• That included our development of the Pureodine™ process (now in its 8th generational iteration), which includes specialized equipment (some customized),.
• Lab-grade manufacture-standardized methodology and protocols.
• And, an advanced ground-breaking proprietary technology exclusive to Cedar Bear® not used by anyone else.
• That technology is our IHMVAS™ (Integrated Hydro Molecular Vortex Agitation System) accelerator that imparts transformative qualities and enhanced glycero-protective/solvent caging stability of the finished molecular iodine (I₂) product.
• The theoretical enhancing of the protective/solvent caging property (a micro encapsulating-like protective effect) by the IHMVAS™ accelerator to the Pureodine™ process is similar in effects to the TincTract® processes' enhancing glycerin's protective/solvent caging properties in our herbal glycerite concentrates, even though they are two unique process technologie.
• While both utilize glycerin, they utilize different equipment, implements, protocols, and raw component ingredients from each other.   

Like our TincTract® process, it's all a patentable development, but we kept it a proprietary trade secret. This all results in an innovative, revolutionary, and unique molecular iodine glycerite for iodine loading protocols and daily iodine supplementation. Its quality, astounding stability, gentleness, and milder flavor are unmatched by any others for this type of iodine product.

We were the first and original diiodine-molecular iodine (I₂) supplement producing company in the industry to drop using the incorrect and chemically obsolete term 'nascent' in favor of the chemical-accurate term and description of 'Molecular.' In "DETAILED REVIEW OF THE SUBJECT" section below, we explain the reason for doing this. This is another example of Cedar Bear Naturales® high quality standards, that also applies to being in line with current scientific nomenclature and descriptions, and being more truthful and accurate describing our products to the resellers and consumers who purchase and use those products.

XODINE™ Molecular Iodine is a 'Standardized' Lab-Grade product produced in a FDA Registered & Audited facility/operation, that is also NSF GMP Certified, subjected to 3rd Party Lab Analysis & Tests, and is KOSHER Certified, HALAL Certified, Vegan Certified, and Made in the USA. 

A DETAILED REVIEW OF THE SUBJECT

It's a lengthy and informative read, so grab a cup of coffee or tea, and kick back for a learning adventure in iodine chemistry for the lay person and technically inclined, and the numerous aspects surrounding iodine for health.

Regarding the two main different forms of consumable iodine/iodide products, one – conjoined mineral salt triiodide ( I₃⁻), such as KI and NaI, and the other – single element-based diiodine-molecular iodine (I₂), such as XODINE™ Molecular Iodine  .....

OF SPECIAL NOTE: There is not a single 'comparative' scientific study or clinical trial regarding the two main different supplement-based consumable forms of iodine/iodides and the differing states of those forms of iodine/iodides resulting from their manufacturing processes and ingredients used in their making. 

That's right! NO head-to-head comparative scientific studies or clinical trials regarding the two forms of consumable iodine/iodides. Yet arbitrary declarations, stances, and posturing are taken by the scientific and medical communities regarding an assumed commonality between these two forms of iodine/iodides based solely on suppositionally-driven logic and a sort of anecdotal thinking that would be considered unacceptable for other subject matters in fact-based science and medicine.

And, regarding the use of the term 'Nascent' for describing a diiodine-molecular iodine (I₂) product, of which ALL so-called 'nascent' iodines are  .....

It is incorrect and highly unscientific to use the word 'Nascent' to describe diiodine-molecular iodine (I₂) supplement products. The concept of 'nascent state' in chemistry is outdated and considered obsolete (though the term is 'conceptually' used in chemistry). Therefore, the name 'nascent' iodine is a misrepresentation and inaccurate description of the actual nature and form of diiodine-molecular iodine (I₂) preparations, especially when the classical definition of the term 'nascent' is considered. 

The term 'nascent,' as popularly and incorrectly used for describing diiodine-molecular iodine (I₂) products, has been used since 1931, named from a psychic's impression, not from a scientific perspective, and is deeply imbedded in the natural health products market psyche as a result. Fact is, describing diiodine-molecular iodine (I₂) products as being 'nascent' is incorrect, and unscientific. 

This form of iodine/iodide is not a 'nascent' product in any sense of the meaning or definition. If it were, such iodine products would not be safe, especially for consuming. While diiodine-molecular iodine is the I₂ form of iodine, in 'conceptual' chemistry a nascent form of iodine would be Iº (not I₂), which is an unbound free ion form of iodine, the most unstable, reactive, and caustic form of iodine there is. The pure 'free' Iº is highly toxic, corrosive, and reactionary to both inorganic and organic matter. Correct use of nomenclature, and understanding those terms is everything in the world of science in general, and chemistry specifically, and is just as important in the world of dietary supplements.

For instance, "Nascent," in common parlance, is defined as 'forming,' 'coming into being,' 'emerging,' and 'evolving,' usually coming from and into a 'free' state, which are all, from a conceptual chemistry  and nomenclature perspective, deemed highly unstable and reactionary states. In chemistry the word 'nascent' has been supplanted by words and terms that are more contextually specific to a chemical action, reaction, or state, and is only used as a conceptual premise, not as a 'fact-based' principle. 

Where diiodine-molecular iodine (I₂) products are concerned, 'nascent' implies that it is the monoatomic (atomic) Iº form of iodine in a free unbound state that is contained in what are actually diiodine-molecular iodine (I₂) products. A monoatomic (atomic) iodine, chemically and biochemically speaking, is a 'free' Iº iodine in fluid systems, that by itself (meaning, not organified or bound to), would be, on contact, toxic, highly corrosive, and a reactive form of iodine, of which diiodine-molecular iodine (I₂) products are not. To be sure, biochemically speaking, the monoatomic (Iº) form of iodine does not come into being in the body until the thyroid, for a brief moment, converts I˜ into monoatomic Iº ion and then immediately organifies (e.g., bound to proteins) it into the form of iodine that is then trapped in the iodine receptors of the thyroid and tissues throughout the body. But as pure free, monoatimic (Iº) iodine in a supplement-based solution, free-roaming in the gut and fluid systems of the body, is not the case, and if so would have disasterous results. 

These are all fundamental facts regarding iodine chemistry and the biochemistry of the body, and yet the purveyors of so-called 'nascent' iodines continue to refer to their products as being 'atomic' (i.e., monoatomic) iodine (Iº), not realizing or ignoring that by the use of term 'nascent,' they are actually implying their particular iodine products are toxic, highly reactive, and corrosive to tissues. Kind of like the proverbial "Shooting themselves in the foot!"

The fact is, companies making and selling their differing takes on so-called 'nascent' labeled iodine for supplement use, do not contain Iº (i.e., 'atomic' iodine) in its unorganified 'free' state, which would possess 'nascent' kinds of instability, corrosiveness, and reactivity, but instead such products actually contain diiodine-molecular iodine as I₂, that is not Iº, which means it is NOT nascent. I₂ (i.e., molecular iodine), in solution, is more stable then Iº (i.e., atomic iodine). The science and nomenclature of chemistry clearly designates a diiodine (I₂) form of iodine, the kind used in products that are called 'nascent,' as being radically different from pure 'free' monoatomic (atomic) Iº iodine, of which Iº, chemically speaking, is closer to the unstable and reactive chemical characteristics of 'nascent.' 

For decades, the makers of other diiodine-molecular iodine products have claimed their product contains monoatomic (i.e., 'atomic') iodine (i.e., Iº), with some even referring to their products as 'Atomic' iodine, which again, from a chemistry perspective, is absurd, inaccurate, and untrue. Such iodine products are not or never were 'nascent' or containing an iodine in the pure free Iº monoatomic state.  Again, we are referencing fundamental iodine chemistry here.

With this knowledge and understanding, Cedar Bear® no longer lists 'Nascent' on its product labels and in print and media. Cedar Bear® will present its Pureodine™ processed diiodine-molecular iodine (I₂) product, XODINE™, as a 'Molecular Iodine.'

Closing on this point, our Pureodine™ processed iodine is NOT a corrosive and reactive 'nascent' monoatomic Iº form of iodine, as,  again, chemically speaking, the name 'nascent' actually implies. XODINE™ is more accurately a standardized 'Stabilized' Diiodine-Molecular Iodine (I₂) Glycerite. We call it for what it actually is, and hence, not something it is not. We try our best to adhere to non-contradictory chemistry-accurate nomenclature where our products are concerned.

Iodine is incredibly important for the body. And make no mistake, iodine deficiency, especially sub-clinical Iodine Deficiency Disorders (IDD) of populations worldwide, including North America, are real and not just a 'popular belief' thing, but are verified and recognized by the United States National Institutes of Health (NIH), Centers for Disease Control (CDC), American Medical Association (AMA), and the World Health Organization (WHO), regardless of what the government and doctors would juxtapose around, gaslight, or have you iodophobically believe.

Iodine is an "essential" mineral for human health and needs, meaning the human body does not make its own iodine but must ingest it, through diet and/or supplementation to get it.

Many evolutionary biologists consider iodine the mineral element that anchors all other minerals in the biological processes of evolution for multi-cellular higher forms of life, hence being called 'The Anchor Mineral.' Iodine possesses the lowest mass to highest weight of the essential mineral elements required by the body, which is one of the reasons it is only needed in trace amounts compared to the other essential minerals. Nevertheless, even in trace amounts, people are still showing iodine-related deficiencies. 

In evolutionary biology, iodine is considered the core antioxidant that enabled the leap to higher forms of life. Antioxidant activity is fundamental to the survival, adaptation, and evolution of aerobic-driven life and plays a crucial role in the evolution of complex organisms and higher forms of life. For sure, iodine was essential to the evolutionary development of warm-blooded species and their thyroid gland. In fact, evolutionary theory states that iodine is at the core of mammalian hemispherical brain development and humans' greater degree of functional lateralization and anatomical asymmetry of the brain. This evolutionary development became unique to humans and would not have happened without iodine.   

While other mineral elements are important and essential, Iodine is the most essential mineral element to healthy DNA sequencing and resultant cellular integrity (the epicenter of chromosomal activity), being another example of iodine's essential role in evolutionary biology and its role in preventing chromosomal anomalies, from the start of in-utero meiosis through fetal development and childhood on through adulthood.

Iodine anchors thyroid activity and, thus, all metabolic activity in and throughout the body. Cardiovascular, blood sugar, and immunity health are just three of the many body systems dependent on a healthy thyroid and adequate iodine intake, uptake, and utilization throughout the body.

The eminent endocrine physician, Broda O. Barnes, MD, specializing in thyroid medicine, proved over a decades-long career that adequate supplemental iodine intake, as a part of his successful regimes, consistently reversed or substantially lessened diabetes and certain heart diseases.

Now, add the ubiquitous presence of bromides in foods, beverages, and commonly used cooking oils, fluoride in municipal water supplies and medicines, and ever increasing background radiation, that all challenge thyroid and systemic tissue iodine uptake and utilization, and the various conditions that result therefrom become even more aparent and of greater concern.

Did you know that bromide is an iodine mimicker and displacer, and an aggressive endocrine disrupter? It displaces iodine and gets trapped in tissue iodine receptors in place of iodine, causing all kinds of undiagnosed, misdiagnosed, and mysterious problems, as well as thyroid hormone imbalances. Many practitioners consider bromide dominance in Americans to be endemic in the population at large, and the cause of many misdiagnosed and undiagnosed conditions. Only adequate daily iodine intake, coupled with substantially reduced intake of bromide-laden foods, beverages, and cooking oils, can reverse bromide loading and re-saturate the thyroid and extrathyroidal tissue iodine receptors of the body with iodine, and keep iodine trapped in the iodine receptors of the thyroid and tissues of the body.  

Since the immune system is embedded into every body system, including the body's metabolic system, the omnipresent immune system relies on the proper functioning of the body's metabolic system to stay strong. Iodine can be incredibly useful in helping to boost the immune system, while also building the immune system at the same time.

There are long-term human and natural caused radioactive events that have caused and continue to exacerbate thyroid function, chromosomal integrity, and immunity, such as human-caused radioisotope-laden high carbon output industries and natural-caused volcanic activity for instance. But, for North Americans, perhaps the most insidious and ubiquitous presence of active and residual background radiation came from the human-caused atmospheric, ground-level, and subterranian nuclear bomb testing that took place, without compunction, at the Nevada test site from 1951 to 1992 (41 years), and still affecting the environment and communities and their surrounding areas. 

Those years of careless unfettered testing resulted in decades of continious barrage after barrage of sand grain sized radioactive particles falling to the ground within a couple hundred miles of the test site, and smaller, but as dangerous and insidious radioactive particles, able to travel the atmospheric jet streams, falling and contaminating the whole of the United States and parts of Canada. Those radioactive particles that fell to the ground, and are everywhere, have a half-life of up to 10,000 years. And no, it's no small amount we're talking of here. The official count of 928 tests over four decades resulted in a massive compounding concentration of radioactive fallout and soil contamination.

Those radioactive fallout radioisotope particles are in all soils of America, and continue to be taken up and absorbed into fodder crops for livestock, agriculturally grown foods, and ground waters, that all make their way into foods and potable water supplies. The effects are ubiquitous, insidious, continuing, and ever present, often of a stochastic nature – not showing up for decades after exposure. Geiger testing of the ground within the couple hundred miles of the testing site still continues to show disturbingly high levels of surface radioactivity, with substantially higher population growth and density or increased recreational use on many of those sites.

More insidious yet, the government keeps upping the threshold safety level for radiation uptake in livestock fodder, foods and water, and exposure and concentrating in livestock and humans, which in every case is much higher now then when safe threshold determinations were first done over six decades ago, intended to give a false impression that somehow there's nothing to worry about regarding radioisotope incursion upon and into the body, even though there is a steady upticking of cancers, heart diseases, ever increasing autoimmune conditions, lessened immune integrity of populations, etc.  

Now, add Soviet era Chernobyl, Ukraine nuclear disaster, a human-caused event, and Fukushima Daichi nuclear disaster, a natural-caused event, that continues to contaminate the Pacific ocean and surrounding seas at unchecked rates, and the compounding effects of active and background radiation on thyroids, chromosomal integrity and immunity becomes undeniable. The fact is, Nevada testing after effects, and Chernobyl and Fukushima disasters, separately and taken together, are ongoing and compounding problems that won't go away for thousands of years. 

So, how does one deal with all the active and background radiation humanity is being subjected to at rising, compounding levels? The answer is – the only effective counter-deterent measure to reducing or preventing the effects of ubiquitous active and background radiation is sustained and adequate intake of non-radiation contaminated iodine-rich foods (which are getting harder to find), or better yet, adequate daily supplemental intake of an appropriate form of iodine, such as XODINE™ Molecular Iodine.  

An important consideration few people, including many health practitioners, are aware of, is that different forms of iodines/iodides are NOT the same and are treated differently, in a nuanced way, in the body relative to their effect on biological systems. Current science orthodoxy 'assumes,' via suppositional logic, that all forms of iodine act the same on biological systems (specifically the gut enzymes and digestive juices, etc.), even though this aspect has been well studied, scientifically researched & elucidated, without seriously considering or even studying the differing states they may be in and how biological systems can affect these forms of iodine separately from each other, especially regarding the Wolff-Chaikoff (W-C) Effect potentials between the two forms of iodine/iodides that would play heavily in determining safe daily intake values for each form separate of each other, and hence, a redoing of the RDA/DV regarding iodine, as well as ascertaining any other observed differences between the two that comparative studies and clinical trials might uncover.

Ignoring the distinctive differences between the two primary forms of consumable iodines/iodides is a prime example of scientific arrogance run amok, and some might say a cognative dissonance-driven sort of arrogance, given that beyond general digestive tract and blood absorption studies and data for iodides, that have been solely focused on mineral conjoined triiodide of iodine (I₃⁻), specifically KI (Potassium Iodide), as previously pointed out, NO actual comparative clinical trials comparing the two different forms of iodines/iodides has, by the scientific community's own admission, been performed. Yet they continue to make and hold to their imperiously imposed suppositional-driven assumptions and dogmatic stances, even though no actual comparative clinical trials supports their positions. 

In other words, convenient suppositions and assumption, though seeming rationally valid at a highly superficial level, not actual comparative scientific studies or clinical trials, have ruled the iodine narrative, even up to now! 

This was a surprising revelation for L. Carl Robinson, the lead developer of the totally alcohol-free Pureodine™ diiodine-molecular iodine (I₂) making process, and was the primary reason he set about to do a deeper dive study of what he called 'the Iodine Conundrum,' that led to his conceiving a more rational solution to developing a better 'Fit-For-Use' daily dietary iodine supplement, and provide a more chemically accurate description for this form of iodine/iodide and the differences between the two main forms of consumable iodine/iodides available. 

Cedar Bear® offers its amazing Pureodine™ processed iodine supplement described as a unique and the 'original' standardized 'Stabilized' Diiodine-Molecular Iodine (I₂) Glycerite. This means no other mineral, like is seen with conjoined mineral salt triiodides ( I₃⁻), such as potassium, sodium, etc., is used to make our iodine. Only the mineral element of iodine, as 'molecular' iodine (I₂), also referred to as  a'diiodine,' and the solvent glycerin are used in making our unique liquid iodine product utilizing the innovative Pureodine™ process, hence its being classified as a singular element-based mineral compound. It is also the first of its kind in the industry and the 'original' glycerite of diiodine-molecular iodine (I₂) supplement in the marketplace.

The chemical process of turning the raw molecular iodine (I₂) into our 'Standardized' glycerite of stablized diiodine-molecular iodine (I₂) is done through our Pureodine™ process, with the IHMVAS accelerator enhancing finished product quality and microencapsulating-like protective effect stability, and done without alcohol or the addition of other conjoining mineral elements such as potassium, sodium, etc. Being a Pureodine™ made 'stabilized' diiodine-based molecular iodine (I₂) means the iodine solution is remarkably stable and with enhanced 'protective/solvent caging' (i.e., similar to the 'microencapsulating-like' protective-stabilization effect) of the I₂ molecules. As previously described, we use the term 'stabilized diiodine’ because it more accurately describes the state of our Pureodine™ processed form of iodine than the term ‘nascent’ does.

Cedar Bear® Stabilized Iodine-Molecular Iodine (I₂), is an alcohol and gas-free made supplement, made using our revolutionary proprietary totally alcohol-free Pureodine™ process, that you can use to help introduce a more gentle and systemically-transitional kind of iodine into your body. XODINE™ Molecular Iodine's stabilized I₂ is one of the most biochemically acceptable forms of dietary iodine supplement there is for easy and effective iodization of the bloodstream. 

As previously stated, it was the first and 'original' alcohol-free glycerite of stabilized 'Standardized' diiodine-molecular iodine (I₂) of its kind in the industry and introduced into the marketplace for iodine loading protocols, and dietary supplement use, and has remained unique, 'original' to Cedar Bear®, and at the forefront ever since.Cedar Bear® has been involved in providing high-quality natural-based 100% alcohol-free liquid supplements to customers for over 40 years, and they have the knowledge and expertise to help you realize the power that natural herbal and mineral supplements can have for you. 

What follows is how iodine can affect metabolism and the immune system, and how Cedar Bear®'s Pureodine™ made Stabilized diiodine-molecular iodine (I₂) comes into play. For a lay reader or the technically inclined, it is one of the most chemistry-accurate overview descriptions and information yet presented for single element based diiodine-molecular iodine (I₂) chemistry and its nuanced activity and affects in the body. Read on ...

Metabolism and Immune System – Overview of Iodine Chemistry & Biology

The immune system is the most 'systemic' system there is, as it is not a singular site (like the digestive or kidney/urinary systems) or singular biological system (like the digestive juices or lymphatic fluids). Some might say it is the most intersystemic and complex of all body systems.

The immune system is imbedded in all the systems of the body, and is vital for your body to ward off harmful bacteria, viruses, and harmful incursive pollutints, and to deal with cells and endogenous by-products that may become destructive to the body. It helps prevent us from getting the flu when others around us are coughing. Your immune system depends on the body's thyroid-driven metabolic systems for the energy and biological factors to fight off illness and dispose of dead cells and neutralized toxins. Without the proper minerals, fuel, and enzymes, along with plenty of water and oxygen intake, the body cannot muster a stable and reliable defense against illness, foreign incursion into the body, or the effects of rapid onset aging.

Metabolism is regulated by hormones produced by the thyroid and throughout the body. Iodine is the thyroid’s physiological and biochemical 'cornerstone' that is essential to creating these hormones, and without proper amounts of the right form of iodine in the thyroid, specifically as in-vivo biogenic-adapted and stabilized Iº (i.e.,'organified' monoatomic iodide), 'trapped' in the cellular colloid and iodine receptors of the thyroid and cells throughout the body, the entire body is negatively affected, including the immune system. However, this stable endogenously 'organified' monoatomic (Iº) form of iodine forms within the thyroid, not outside of it, as this Iº form of iodine, if found in an unorganified 'free state' outside the stable and organified environment of the iodine receptors of the thyroid and cells of the body would be toxic and destructive to tissues.

Recent scientific studies show that iodine-related activity goes beyond the thyroid gland, though the thyroid represents the lion's share of iodine-related activity in the body, but is also present, to one degree or another, in every cell and system throughout the body. It is here that molecular iodine, as I₂, in a carrier-bound transport form, that happens in the digestive tract, is involved in the extrathyroidal sites of the body where it is in turn configured to an appropriate form to be trapped in the iodine receptors of extrathyroidal cells of the body. This chemical conversion pathway-membrane diffusion-based uptake of carrier-bound  I₂ from the digestive tract into the bloodstream and transport to extrathyroidal sites is described in the following quoted review of a research abstract from the NIH (National Institutes of Health) National Library of Medicine.

Title of Study Review: 'Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator':  "Most investigations of iodine metabolism in humans and animals have focused on its role in thyroid function. However, considerable evidence indicates that iodine could also be implicated in the physiopathology of other organs. We review the literature that shows that molecular iodine (I₂) exerts multiple and complex actions on the organs that capture it, not including its effects as part of thyroid hormones. This chemical form of iodine is internalized by a facilitated diffusion system that is evolutionary conserved, and its effects appear to be mediated by a variety of mechanisms and pathways. As an oxidized component, it directly neutralizes free radicals, induces the expression of type II antioxidant enzymes, or inactivates proinflammatory pathways. In neoplastic cells, I₂ generates iodolipids with nuclear actions that include the activation of apoptotic pathways and the inhibition of markers related to stem cell maintenance, chemoresistance, and survival. Recently, I₂ has been postulated as an immune modulator that depending on the cellular context, can function as an inhibitor or activator of immune responses. We propose that the intake of molecular iodine is increased in adults to at least 1 mg/day in specific pathologies to obtain the potential extrathyroid benefits described in this review." (Ref: Int J Mol Sci. 2021 Jan 27;22(3):1228.)

Wow! Cedar Bear® Pureodine™ processed XODINE™ Molecular Iodine, being a stabilized diiodine-molecular iodine (I₂) glycerite, is the exact I₂ form of iodine the above study review abstract recommends for increasing daily molecular iodine (I₂) intake. Note that the review abstract does not mention or indicate conjoined mineral salt triiodide ( I₃⁻) as KI (Potassium Iodide), but I₂, as mono element-based diiodine-molecular iodine!

In summarizing the research, the researchers state that the thyroid is not the only place that iodine-related actions take place, but also take place in extraceullular sites, via iodine as I₂. In this instance, iI₂, as organified I₂ is etracellular-trapped, where it becomes an oxidative component (i.e., antioxidant) that directly neutralizes free radicals and triggers type II antioxidant enzymes, suppresses inflammatory pathways, enhances healthy stem cell activity and cellular chemoresistance and survival, and an up-or-down regulating immune modulator. And more can be surmised as beneficial ancillary actions from those listed herein, along with yet to be ascertained benefits.

That's what the carrier-bound I₂ form of iodine results in throughout the extrathyroidal tissues of the body, but only when there is an adequate iodine reserve trapped in the thyroid colloid and extrathyroidally throughout the body, which can only happen with adequate daily intake of iodine, which is generally not the case, which is why the afore referenced research reviewers proposed increasing the intake of diiodine-molecular iodine (I₂), that can only be done via iodine-rich foods, conjoined mineral salt triiodides ( I₃⁻), and moer preferably, single element based diiodine-molecular iodine (I₂) (such as XODINE™ Molecular Iodine, which is the straight-up molecular I₂ iodine referred to in the above quoted study review), for specific extrathyroidal pathologies to at least 1mg/day, which is many times more than the US governments paltry and absurdly low RDA/DV listing for daily iodine intake. Even so, with rampant and sub-clinical IDDs ubiquitious presence in the population, this increase in daily iodine intake also merits consideration for non-pathological tissue iodine loading and daily supplementation to at least the RDA/DV levels recommended in the above quoted study review. 

In the digestive tract, Pureodine™ processed XODINE™ Molecular Iodine, being a diiodine-molecular iodine (I₂) configuration is subjected to digestive juices and enzymatic activity that collapses and dissociates the I₂ into its two constituent I˜ parts, that are also carrier-bound and absorbed from the gut epithelium into the bloodstream, via the sodium–iodide symporter (NIS), and as previously shown, some of the I₂ from the consumed stabilized diiodine-molecular iodine (I₂) remains intact, and is also carrier-bound via other non-NSA chemical conversion pathways-membrane diffusion and absorbed into the bloodstream, where both the I₂ and dissociated mono iodides (i.e., two I˜) are transported to appropriate thyroid and/or extrathyroid tissues throughout the body. Hey! We're talking fundamental iodine-related biochemistry here.

All consumed iodine/iodides, regardless of source or form, whether from foods, conjoined mineral salt triiodides, or diiodine-molecular iodines, once consumed and in the digestive tract, go through a highly sequentiated cascading series of digestive juice and enzymatically-driven states, that concludes with absorption into the bloodstream and transport to the thyroid of I˜ or extrathyroid sites of I₂, where in the thyroid I˜ is turned into the biogenic-adapted monoatomic form of organified Iº that the thyroid sequesters and utilizes, and the molecular iodine (I₂) is extrathyroudally converted and utilized by the other cells and tissues of the body.,  

In the instance of I˜, if the thyroid doesn’t absorb, convert to Iº, and biogenically organify the Iº, and then trap it in the thyroid's iodine receptors, it has to work harder to produce even less than needed thyroid hormones, and it can cause swelling and inflammation that leads to myxedema, a goiter, and eventual stoppage of thyroid hormone production altogether. 

For instance, myxedema, a swelling/puffiness of the skin and underlying tissues giving a waxy consistency to the skin, with a swollen/puffy neck/throat, is typical in people with underactive thyroids, with the condition generally associated with hypothyroidism, that typically includes weight gain, mental dullness, random energy dumps, and sensitivity to cold. It is a common condition in the population, that many health practitioners believe is largely driven by bromide-loading (which displaces iodine from the body's tissues) from commercially processed foods (especially flours and baked goods), carbonated beverages, the most commonly used cooking oils, and conventional agricultural/hortocultural practices. It is considered a significant sub-clinical Iodine Deficiency Disorder (IDD). However, if myxedema progresses to a more serious state it can result in goiters and serious immune and health problems.  

The science clearly shows that a gross deficiency of iodine at the thyroid's iodine receptors is a major cause of myxedema, early onset & advanced hypothyroid, and goiters. Goiters are a swollen thyroid gland condition and may represent a full-on clinical IDD. Goiters can manifest in either a hypothyroid or hyperthyroid condition. Goiters (along with bulging eyeballs) represent the most serious outward manifestations of a full-on clinically-based hypothyroid or hyperthyroid condition and require medical interventions. Of note, a hyperthyroid condition is rare, and from a population-wide perspective, happens far less than is seen for hypothyroid conditions. 

It is often believed that vitamin C and vitamin D are the primary 'go-to' for a healthy and strong immune system. While these and balanced levels of other vitamins and minerals are important and should not be ignored, iodine is seen by many as being the anchoring and most foundational to a strong, healthy immune system. Many problems that appear to be vitamin C deficiency related, for example, may be more indicative of an iodine deficiency, especially if a vitamin C regime is minimal or doesn't resolve a condition it is recommended for. Many unresolved conditions utilizing other nutritional supplements are often resolved when a Pureodine™ made stabilized diiodine-molecular iodine (I₂) glycerite of XODINE™ Molecular Iodine is used, either by itself or in combination with those other nutritional supplements, especially selenium, which is essential to iodine utilization in the body.

As earlier described, iodine is great for providing direct immune system support and maintaining DNA sequencing integrity. Iodine helps keep cells healthy and normal, and when at adequate tissue iodine saturation levels, helps keep the body free of toxins. An internal environment rich in iodine is unable to host harmful bacteria, viruses, and fungi that make us sick, and it has been found that these microorganisms cannot adapt to an iodine-enriched tissual environment. 

Take Candidiasis fungi for instance. In the digestive tract it is one of the most difficult conditions to overcome and remove. High milligram doses of diodine-molecular iodine (I₂) solution, well beyond 3 mg, has been recommended as a non-drug approach to dealing with Candidiasis. However, be aware that if higher milligram dosing of iodine is done, regardless of the form of iodine supplement used, it will likely trigger an acute W-C Effect (i.e., Wolff-Chaikoff Effect – addressed later) as a side effect of the sudden high milligram dosing protocol (also called 'shock' dosing), but will pass once the high milligram dosing ceases and daily dosing is taken back to around 3 mg or less. Like many things in health care, to affect an outcome with a protocol can carry a side effect with it. However, such planned for and quickly resolved side effects are sometimes part of an integrative healing approach. 

And, not to be forgotten, an iodine-enriched tissual environment also provides for healthy neural activity and brain synapses, and contributes to judicious cognition and rational behavior,

The amazing part of this is that compared to other minerals and vitamins intake, the amount of our Pureodine™ processed XODINE™ Molecular Iodine of diiodine-molecular iodine (I₂) intake is extremely small. On a normal basis, only 6 drops a day! (3 to 4 drops for children.) is recommended. Yet it provides more than the absurdly low government's Recommended Daily Allowance (RDA)/Daily Value (DV) listing, while appearing still low enough to not trigger a W-C Effect in the body, that when compared to the huge benefits resulting therefrom, makes our XODINE™ Molecular iodine one of the most astounding value propositions of all essential nutrient supplements there is.

Iodine is found naturally all over the world in some soils, deep earth venues, in the oceans, and the atmosphere – especially over the oceans, where the oceanic/atmospheric 'Iodine Cycle' profoundly influence natural climate control and building/maintaining the ionosphere. Cedar Bear®’s raw iodine used in the making of its Pureodine™ made stabilized diiodine-molecular iodine (I₂) glycerite is from deep earth sources that, unlike ocean-sourced iodine, have been protected for eons against atmospheric and surface contamination, radiation (background and incursive), and modern pollutants.

While it may be remotely possible to get enough unimpeded iodine intake from diet alone, which is extremely rare, most people worldwide are susceptible, to one degree or another, to iodine deficiency due to a number of reasons. Recently, iodine deficiency has gained increased awareness, and so it is becoming more widely available. Historically, iodine, as potassium iodide, has commonly been added to table salt to provide an easy method of iodine access. It is estimated that around 70 percent of people around the world have access to iodized table salt, though it may be their only source of iodine supplementation available. however, the iodine in iodized salt liberates and dissipates over time due to its generally being in paperboard-based containers that expose the salt and potassium iodide to ambient air, and if left on shelves too long without using, which warehoused iodized table salt is often subjected to (especially where high temperature and/or high humidity environment is present), iodized salt looses most of its iodine to sublimation (i.e., liberating as a vapor due to ambient air exposure).

Up until the early 1980s, America mandated that iodine not only be added to table salt, but also be added to all commercial grain-based bakery goods, with no bromides allowed. This was because throughout the 1800s and early 1900s America population experienced goiters on an endemic level across the nation, which was traced to gross iodine deficiency of the population. After the mandate was lifted in the 1980s, and iodine was no longer required in baked goods (or even table salt), bromides were almost immediately added to commercial flours and baked goods as 'bleaching aids,' and 'dough conditioners,' to the point that bromides, and their iodine displacing and endocrine disruptor effects, are ubiquitous in baking flours and commercial baked goods, as well as ubiquitous in carbonated beverages and the many commonly used cooking oils. Of further note is that since the goiter criis of the 19th century/early 20th century, North America's commercial agricultural and food growing soils have contintinued to degrade, including becomming more and more iodine deficient in the ensuing decades due to soil-depleting agricultural practices and radiation-laden contaminating of soils (that binds any traces of iodine left), meaning that the claim or belief that foods grown on North American soils posses enough iodine traces to satisfy daily dietary intake of iodine is simply not possible. Sadly, today, myxedema and goiters are rarely corrected with increased prophylactic iodine intake protocols followed by adequate ongoing daily iodine supplementation recommendations, but are dealt with by using various pharmaceuticals that may include synthetic thyroid hormones, thus bypassing the thyroid altogether, or killing the thyroid and forcing a person to have to take synthetic thyroid hormones for the rest of their lives, that includes all the side effects and immune weakening effects that accompany those drugs.

Bromide-loading overwhelms daily iodine intake and tissue iodine levels in the body, resulting in bromides displacing iodine at the tissue iodine receptor sites. This is a ubiquitous event affecting all of American society, especially since, unlike Canada, Great Britain, Australia, New Zealand, and the European Union, America has not banned the  use of added bromide/bromines in consumable products. That point alone is reason enough to substantially increase daily iodine intake with XODINE™ Molecular Iodine.

When one is able to wade through the road-blocks of determining how much bromide is being consumed daily from bromide-laden commercial foods, carbonated beverages, and most common cooking oils (In America, bromides are not required to be listed on ingredient labels), and compares that ascertained average daily bromide intake amount against the paltry and absurdly low governments RDA/DV for iodine they should be consuming, but in all liklihood are not, it becomes quickly apparent that daily bromide intake by the average grocery shopping American for commercial processed foods, carbonated beverages, and the most widely used cooking oils, are bromide loading them and their families at a bromide DV (Daily Value) that far exceeds that for the RDA/DV for iodine. Hence, the sub-clinical IDD (Iodine Deficiency Disorder) that is insidious (not apparent) and ubiquitous (omnipresent) in the population, and a ticking time bomb regarding health problems.

Some claim to be 'allergic' to iodine because they cannot eat shellfish, which causes reactions. Well... an allergy is caused by a 'protein,' not a mineral. This is an indisputable fact! One cannot be allergic to a mineral because a mineral is not a protein, this includes iodine. The shellfish contains a protein causing an allergy, not the iodine. There may be a 'chemical' sensitivity to iodine, which is extremely rare, but never an allergy to iodine.  

Aside from the limited availability in foods, Iodine is also consumed as a dietary supplement. Many live in places where the soil does not have enough available iodine traces to make its way into the food chain, especially where bromine/bromide-containing agricutural chemicals are widely used on soils and on growing foods, that displace those iodine traces, which is now found across most of the planet's landmass, which makes iodine supplementation necessary, especially if the government's absurdly low RDA/DV for iodine is held to and not raised, which is guaranteeing population-wide deficient iodine intake that may cause sub-clinical IDD for many and full-on clinical IDD for others. 

Iodine supplements can be found in liquids, tablets, capsules, and, as mentioned before, iodized table salt (if it hasn't been warehoused for too long before getting on to store shelves). In typical settings, the iodine is in the form of a conjoined mineral salt triiodide (I₃⁻), the most common being potassium iodide or variants thereof, and that kind of iodine may not be the best 'Fit-For-Use' iodine for daily dietary supplementation, as you will see in the next section.

The Pureodine™ Process – An Industry First, and Marketplace Original

Cedar Bear® Glycerite of 'Stabilized' Molecular Iodine – A Diiodine (I₂) of Iodine

To be clear again, all so-called nascent iodine products on the market are not 'nascent' per se,' but are, chemically speaking, a 'Diiodine-molecular' (I₂) Iodine. In iodine chemistry 'molecular' iodine is referred to as I₂, a diiodine of iodine. Prior to Cedar Bear®'s introducing its industry-first and the 'original' 'glycerite' of XODINE™ Molecular Iodine dietary supplement product into the market, other companies diiodine-molecular iodine products were, and still are, made with alcohol, water, or might include gasses, such as chlorine or ether, as part of their manufacture processes. The Pureodine™ process does not use alcohol or gasses. It uses glycerin as the dissolving, protective solvent caging, and stabilizing agent.

First developed in 2007, the proprietary Cedar Bear® Pureodine™ process for making XODINE™ Molecular Iodine results in a  single element based diiodine of stabilized molecular iodine (I₂), combined with glycerol, in a transformed, stability enhanced, 'protective solvent caged' aggregate state. It's unique to Cedar Bear®'s Pureodine™ process and a first and 'original' in the marketplace and the iodine tissue loading and dietary supplements industry.

After Cedar Bear® introduced its glycerite of stabilized diiodine-molecular iodine (I₂) into the market, others attempted to duplicate our glycerite-based iodine approach, both as conjoined mineral salt triiodides (I₃⁻),  and other diiodine-molecular iodine (I₂) offerings. However, they are not made the same way nor possess the unique qualities that the Pureodine™ process, with its IHMVAS accelerator, imparts to its stabilized diiodine-molecular iodine (I₂), such as being milder tasting, gentle on oral and gut tissues, more transitional breakdown and carrier-binding processes in the gut (which accounts for why it is gentler on the gut than conjoined mineral salt triiodides), and sustained uptake into the bloodstream of both the I˜ constituent parts of the I₂ molecule and intact I₂ molecule itself, requiring less per daily dose for anticipated benefits than other manufacturer's diiodine-molecular iodine products. 

A Pureodine™ made XODINE™ Molecular Iodine is made using deep-earth-sourced pure USP-Grade iodine in its crystaline molecular (I₂) state, along with USP-Grade, Kosher and Halal Certified, GMO-Free vegetable glycerol (glycerin), and is never conjoined, bound to, or in combination with any other mineral element like other conjoined mineral salt triiodides (I₃⁻), such as potassium, sodium, etc.

For instance, Lugol’s solution of iodine, derived from raw iodine crystals, as anhydrous molecular iodine (I₂), is conjoined with potassium. And, Iosol™ iodine is conjoined with sodium, both resulting in a triiodide (I₃⁻) of iodine. These manufactured chemically reduced conjoined mineral salt triiodides, and others like them, when entering the stomach, readily give up iodide, as I˜, that is quickly bound to NIS and absorbed into the blood stream, which may account for why conjoined mineral salt triiodides (I₃⁻), such as KI (Potassium Iodide), is the preferred prophylactic, in sudden high 'shocking' doses, that in turn causes the Wolf-Chaikoff Effect (W-C Effect) of quickly staunching NIS binding/transport activity, thus suppressing thyroid iodine uptake of radio isotope bound iodine (and all other forms of iodine) in the event of a nuclear or radiation fallout crisis. Here is where conjoined mineral salt triiodide (I₃⁻) is a definite 'Fit-for Use' emergency protocol. In high milligram 'shocking' doses a conjoined mineral salt triiodide (I₃⁻) will more quickly initiate an acute W-C Effect staunching of NIS activity faster than a diiodine-molecular iodine appears to result in. 

On the other hand, a stabilized diiodine-molecular iodine (I₂) does not collapse and dissociate into its constituent I˜ parts as readily and release the mono iodide of I˜ into the bloodstream, via NIS transporter, as quickly as conjoined mineral salt triiodides do. This is because a diiodine-molecular iodine, as I₂, appears to be more stable in solution, including in the gut, especially when in a glycerite-based solution, and thus in the gut requires a more complex digestive juice and enzymatic process to collapse and dissociate the I₂ into its two constituent I˜ parts, with the I˜ becoming carrier-bound, via NIS (Sodium-Iodide Symporter), and then absorbing into the bloodstream, and, a portion of the consumed I₂ remaining intact, and is then also carrier-bound and absorbed into the bloodstream to be transported to extrathyroidal cellular sites.  

The guts handling of diiodine-molecular iodine (I₂) accounts for why this form of iodine is more gentle on the digestive system and the body, more transitionally processed, and its slower uptake of the mono iodide (I˜) and molecular iodine (I₂) into the bloodstream, thus alppearing to be more gentle on thyroid and systemic extrathyroidal tissue uptake of iodine and appearing to not as readily triggering a Wolff-Chaikoff Effect, of which the W-C Effect in turn paradoxically supresses or staunches NIS-bound iodine uptake into the blood stream, and in turn suppress thyroid and systemic extrathyroidal tissue iodine uptake.

The aforementioned phenomenon of the Wolff-Chiakoff (W-C) Effect, staunches NIS (Sodium-Iodide Symporter) binding and transport of all iodine/iodides for a time if too much iodine, as mono iodide (I˜), concentrates to high or spiking level in the blood at any one time, especially if happening quickly in a short period of time, such as happens with 'shock dosing.'

The primary purpose the body enters into the W-C Effect is to prevent runaway thyroid hormone synthesis in the face of mono iodide (I˜) overload. This knowledge explains why utilizing conjoined mineral salt triiodide (I₃⁻) as an emergency prophylactic, in sudden high milligram amounts per dose (called 'shocking'), with its sudden presence of mono iodide (I˜), suppresses the uptake of all iodine/iodides, especially radio-isotope-bound iodine in the event of radiation fallout from a nuclear event.

As previously stated, the W-C Effect suppresses NIS binding and transport of iodine to thyroid and extrathyroidal tissues, which suppresses iodine conversion of I˜ to Iº, thus shutting down 'organification' of iodide (as the 'organified' iodide is the kind used to make the thyroid hormones). Once the sudden high gut saturation of consumed iodine, as mineral salt of triiodide, abates or stabilizes, or a period of time passes, generally around 14 days or so, for the body to adjust and accomodate a sustained high iodine intake, the 'Escape Phenomenon' follows, that allows the suppressed NIS activity to 'escape' from the W-C Effect, with NIS transport activity resuming, and normal iodine uptake and hormone synthesis, via down-regulation of the Sodium–Iodide Symporter, lowering intracellular iodide concentrations, bringing it back below the inhibitory threshold.

The W-C Effect can happen with any form of iodine/iodide, because all forms provide mono iodide (I˜) to the NIS for transport into the  bloodstream, though a conjoined mineral salt triiodide (I₃⁻), due to its faster collapsing, dissociating, and releasing of mono iodide (I˜) into the bloodstream, appears to be more aggressive at triggering a W-C Effect than diiodine-molecular iodines (I₂) appear. This is due to the different state of the two different forms of iodine and how they are dealt with in the digestive system. 

Even so, both forms of iodine/iodides can result in a W-C Effect if too much mono iodide (I˜) from either form of iodine/iodides is released, spiking too quickly or over-saturating at any one time, or potentially from over-concentrating from over-consuming due to the resultant mono iodide (I˜) compounding to too high levels over a short period of time. 

Studies have shown that the W-C Effect, in rare but very thyroid sensitive individuals (Hashimoto's, neonates, or with certain preexisting thyroid diseases), can be triggered with as low as 1-2 mg/day of iodine, which is very rare. In most 'normal' adults it can (note; 'can,' not 'will') be triggered by as low as 3-5 mg/day of iodine, but typically, in healthier individuals, is more in the range of 6-9 mg/day. The W-C Effect is consistently triggered in most adults at 10-20 mg/day. Strong W-C suppression, used clinically in pre-thyroid surgery or thyrotoxic crisis, is at 30-40 mg/day. Definite and longer sustained W-C inhibition (for radio-isotope incursions for example) takes place at 100mg/day until intake is lowered or a substantial period of time has elapsed with the continued high mg/day intake, with the excess being excreted via the kidney/urinary system.. 

Based on approximately 20 years of practitioner and consumer feedback, rhe recommended daily dose for the Pureodine™ processed XODINE™ Molecular Iodine glycerite has been set at 2-3 mg/day (1-2 mg/day for children over 2 years old).

It's surprising that the proven and well elucidated W-C Effect of Iodine, especially regarding mono iodide of I˜acute blood iodine over-saturate loading effects, is missed, passed over, or ignored by many doctors, practitioners, dietitians/nutritionists, and even many holistic oriented practitioners.

Some have even maligned or denied the results of the W-C Effect because Wolff and Chaikoff originally did their studies on rats, and then applied the outcomes to human metabolism (because thyroid physiology/biochemistry are the same for rats and humans). The maligners and deniers do so while conveniently ignoring that the Wolff-Chaikoff studies, outcomes, and interpretations have been subjected to further rigorous follow-up studies, some on human subjects no less, to the original 1948 study and Wolff's re-review of the study in 1969.

Those follow-up studies include the 1988, 2001, and 2014 landmark studies that dived deeper into a highly detailed biochemistry of the subject matter, which solidly applied to human biochemistry and metabolism, and clearly verified and detailingly further elucidated the W-C Effect. Make no mistake! The W-C Effect is real, and is as it has been studied and elucidated for almost 80 years as of this writing. Those who say otherwise have typically only made a shallow or cursory study of the subject and base their views and opinions on an incomplete understanding of the facts, or blindly side with speculative and faulty assumptions of others, based on a cognative dissonance driven cafetria-based pick-n-choose approach of the available information.

Given this information, it appears that a major differences between a conjoined mineral salt triiodide, such as KI or NaI, versus a diiodine-molecular iodine, such as XODINE™ Molecular Iodine, is there appears to be less W-C Effect-driven suppression of NIS binding-carrier activity with a diiodine-molecular iodine product. Again, this premise is based on what we know regarding digestive process effects on the different forms of ingested iodines as triiodides (I₃⁻) versus diiodines (I₂), given the studied and known gut biochemistry of collapsing and dissociating mono iodide (I˜) from both forms of consumable iodides for NIS binding-carrier and absorption into the bloodstream. 

Cedar Bear® founder, L. Carl Robinson, became aware of this W-C Effect information, and its ramifications to human biology through his studies of IDD (Iodine Deficiency Disorders) that led to a deep dive search into what he called the 'Iodine Conundrum.'

As a result, he resolved to figure out the facts regarding the different forms of iodine, how they are dealt with in the body, and their effects in the body, and as a result of his findings, lead developed an alcohol-free and gas-free solution to the problem by pursuing the development of a glycerite of diiodine-molecular iodine (I₂) supplement with transformative and enhanced protective solvent caging properties and enhanced stability, done primarily for safe daily dietary supplement use at reasonable and effective dosage levels. 

What Carl and his select development team developed is quite revolutionary for this form of iodine supplement, and is different and unique, on many levels, from other similar types of diiodine-molecular iodine products.

The upshot being that a diiodine-molecular iodine (I₂) may possess a sort of better in-vivo biological compatability, stability, and more gentle transitional presentation of I˜, and delayed secondary absorption and transport of I₂ to the bloodstream that works more in harmony with the biochemical and physiological  iodine needs of the thyroid and extrathyroidal tissues throughout the body. The key phrase being 'better biological compatibility.'

It is further observed in actual use of the two different forms of iodine/iodides that whereas the conjoined mineral salt triiodide (i.e., KI and NaI) can have, as stated before, harsher and unsettling effects on the digestive system, especially in higher milligram doses, as practitioners and clinicians have noted, due to the rapid collapsing and dissociating of the conjoined mineral salt of iodides, whereas, the diiodine-molecular iodine (I₂), especially the alcohol-free Pureodine™ made XODINE™ Molecular Iodine glycerite, due to its slower and transitory collapse and dissociation into its constituent parts, appears to be more gentle and digestive-friendly on the gut, thus indicating another noted and observed difference between the two different forms of iodine/iodide.

This latter point clearly indicates that conjoined mineral salt triiodides as I₃⁻ (KI, NaI, etc.) may NOT be the best source of daily dietary iodine supplementation, and more so for tissue iodine loading protocols, considering there is a better option available. A conjoined mineral salt triiodide might even be considered 'Not-As-Fit-for-Use' for iodine tissue loading or effective daily dietary supplemental purposes, meaning, if both forms of iodine are available, the diiodine-molecular iodine (I₂), such as XODINE™ Molecular Iodine, would be the preferred choice.

As addressed earlier, the aforementioned easier triggering of the W-C Effect with conjoined mineral salt triiodides, such as KI and NaI, is why the triiodide form of iodine, in super-high shocking doses, is such a good go-to prophylactic for staunching the uptake and effects of radio-isotope bound iodine and affected heavy metal incursions from a nuclear event and its radiation fallout, because conjoined mineral salt triiodides, especially when given in high 'shocking' doses, more radically, through its rapid blood saturation of mono element iodide (I˜), suppresses NIS binding and carrier activity, which stops the thyroid and extrathyroidal tissues of the body from receiving and up-taking all forms of iodine, including radiation laden iodine, than a diiodine-molecular iodine (I₂) might or appears to be capable of doing to the same degree in this kind of an emergency situation. 

Again, indicating another noted and observed difference between the two different forms of iodine/iodides, clearly showing that each appears to be suited to a 'Fit-for-Use' aspect different from each other. Nevertheless, given that no comparative studies have been performed regarding this premise, it is still a subjective perspective, though given what we know, based on blood iodine uptake studies and interpretations, of the digestive dynamics and biochemical aspects of the two different forms of iodine products, the stated premise appears more likely than not.  

Cedar Bear® Pureodine™ processed molecular iodine, sold under the Cedar Bear® brand XODINE®, and also made available through our LHI (Liquid Herbs International™) sales department to third party private label & bulk ingredient accounts, is NOT a conjoined mineral salt triiodide (I₃⁻), but is a glycerite of standardized stabilized diiodine-molecular iodine (I₂), meaning the only mineral element present in our product is iodine, in a transformed, highly stable state. It's a form of iodine that appears to work more hand-in-hand with the body's digestive, metabolic, thyroid, and extrathyroidal needs, since, on a microgram-for-microgram basis, it would possess less of a potential for a W-C Effect than conjoined mineral salt triiodides do, due to its slower, sustained, and transitional release of mono iodide (I˜) into the bloodstream, which is a scientifically established fact regarding how the digestive tract deals with both forms of iodine/iodides.

One point that needs to be pointed out is that some makers of iodine supplements mix a finished diiodine-molecular iodine (I₂) with a conjoined mineral salt triiodide (I₃⁻), such as potassium iodide or sodium iodide, and claim the end product is still a diiodine-based molecular (i.e., nascent) iodine, which, chemically speaking, it is not.

The reason is, chemically speaking, is this is not possible since when molecular iodine, either as a finished diiodine-molecular iodine product, or pure raw iodine crystals is mixed with conjoined mineral salt triiodide, such as is done in strengthening the iodine percentage of Lugol's potassium iodide solution during its making, the added iodine , chemically converts and combines with the conjoined minerals salt triiodide, thus fully becoming a conjoined mineral salt triiodide product, and no longer a diiodine-molecular iodine product.

The Enhanced Protective Solvent Cage Effect of Glycerin & the Pureodine™ Process

L. Carl Robinson, as lead developer, with a small team of co-developer specialists with backgrounds in nuclear science & electrics, and systems engineering theory, created the Pureodine™ technology. It's a proprietary totally alcohol-free and gas-free 'transformative' stabilizing liquid iodine making process, that includes our proprietary IMVHAS (Integrated Hydro Molecular Vortex Agitation System) accelerator technology to create our innovative and revolutionary high-quality protective solvent caged stable glycerite of standardized diiodine-molecular iodine (I₂) supplements without alcohol, gases, or other conjoined minerals in a way never before done. No covalent-bonding of the glycerin to the iodine is happening, so the diiodine-molecular iodine (I₂) aspect remains intact, because the Pureodine™ enhanced protective solvent caging effect upon the molecular iodine (I₂) does not change the bonds between the iodine molecules or the glycerin molecules, as they remain intact, but allows for the glycerin to act in a protective 'shell' fashion, analogous to how a shell protects a crap. 

This was an industry first for dietary supplement-based iodine products and the first and 'original' of its kind introduced into the marketplace. As mentioned at the beginning, the Pureodine™ process is a patentable development, but, like our TincTract® process, we decided to keep it a proprietary trade secret.

As also previously mentioned, the IMVHAS accelerator technology imparts a theoretical  'transformative' weak energy field to the I₂ enriched glycerite solution and a stability-enhancing property to this form of iodine/iodide. Now, orthodox science continues to dismiss, and even malign this 'transformative' premise, even though chemistry fundamentals teach that when a solution of polarized (ionic) elements or a polarized solute compound, such as our glycerite of molecular iodine (I₂) solution, when subjected to an energy field, that energy field has, to one degree or another, an energy capturing or 'transforming' effect on the subject being subjected to an energy field. 

So from a purely chemical, and by association, physics perspective, yes! A Pureodine™ processed diiodine-molecular iodine (I₂) solution IS also an energetically affected (i.e., transformed) product, that would possess unique qualities apart from that of other iodine/iodide products. Hey! We're talking fundamental chemistry and basic molecular physics here!  

And as previously addressed, unlike other diiodine-molecular iodine products, Cedar Bear®'s glycerite of diiodine-molecular iodine (I₂) solution also possesses a unique stability, imparted by the Pureodine™ process, enhancing the protective solvent caging  property of glycerin around the iodine molecules (see above illustrations). It's also believed to be why a Pureodine™ processed iodine is so stable, gentle on tissues, and possesses a milder taste for this type of iodine product. The Pureodine™'s effect on enhancing the protective solvent caging property of glycerin, and its effect on the overall diiodine-molecular iodine XODINE® product's enhanced stability, is absent in other diiodine-molecular iodines (whether alcohol, gas, or glycerin based), or conjoined mineral salt triiodide products. This Pureodine™ protective solvent cage enhanced property and stability of glycerin is also present in our proprietary TincTract® processed liquid herbal glycerite concentrates.

Over the years since Cedar Bear® first developed the Pureodine™ process for making XODINE™ Iodine, others have tried to do their own glycerite versions of a diiodine-molecular iodine, but haven't matched the Pureodine™ process with its IMVHAS accelerator technology, or enhanced protective solvent caging stability, more pleasant taste, and gentler per-dose effectiveness and value of Cedar Bear®'s Pureodine™ processed XODINE™ glycerite of diiodine-molecular iodine (I₂). This is because our Pureodine™ processed diiodine-molecular iodine really is different from all others.

On a final note. An essential benefit of glycerin being used in the making of Pureodine™ processed iodine is that glycerin is much easier on the body than alcohol, residual gases or toxic chemical residues, even possessing nutritive qualities, and assists the body to better transition gut conversion of I₂ into an absorbable iodide state (I˜) that is the only form of iodines that can be converted inside the thyroid into monoatomic iodine (Iº), that is then instantly organified and trapped in the iodine receptors of the thyroid, for thyroid hormones production and for all of the body's iodine-based biological needs. Cedar Bear® Pureodine™ made standardized diiodine-molecular iodine (I₂) glycerite begins to be digested (i.e., collapses), dissociated into its constituent parts, and absorbed into the bloodstream at a more biologically-friendly level, and from there utilized by the thyroid of the body in a transitionally sustained fashion. This also applies to, according to recent research of the past two decades, the portion of I₂ that is transported to extrathyroid sites in the body via a combination of chemical conversion pathways and passive diffusion across membranes.

Recommended Dosing: To use Cedar Bear® Pureodine™ made diiodide-molecular iodine (I₂) glycerite, all it takes is a daily dose of six drops (3 to 4 drops for children) in a glass of purified or distilled water. Drink the water for a light tasting, alcohol-free 'Fit-for-Use' daily iodine supplement that can help provide the iodine your body and immune system need. A one ounce bottle of XODINE™ Molecular Iodine, the first and 'original' alcohol-free glycerite of molecular iodine, will last a person 3 months when used according to the daily dose of six drops per day.

So, there you have it! A detailed introduction to Cedar Bear Naturales® Pureodine™ made standardized diiodine-molecular iodine (I₂) glycerite, and one of the most chemistry-accurate presentations regarding diiodine-molecular iodine, as a dietary supplement, in general, and the standardized Pureodine™ processed stabilized and protective solvent caged enhanced glycerite of diiodine-molecular iodine (I₂) specifically. Cedar Bear® XODINE™ Molecular Iodine is a clearly thought out, carefully executed technology, and the most chemical-accurate understood and elucidated of this form of iodine supplement there is. The choice is clear – XODINE™ Molecular Iodine!  

Get Your Cedar Bear® Glycerite of Diiodine-Molecular Iodine – XODINE™